Ozgüven Atalay, Tünger Ozlem, Cetin Ciğdem Banu, Dinç Gönül
Celal Bayar Universitesi Tip Fakültesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Manisa.
Mikrobiyol Bul. 2008 Oct;42(4):661-7.
The aim of this study was to evaluate the carriage rate and risk factors of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) among the students in Manisa, Turkey. A total of 2015 students (1012 from the last phase of high schools and 1003 from the first phase of primary schools) were included in the study. None of the students had nasal MRSA carriage. Methicillin-sensitive S. aureus (MSSA) colonization rate was 14.7% (296/2015). Nasal carriage of MSSA was significantly higher in the primary school students (17.8%) than the high school students (11.6%) (p < 0.001). MSSA carriage was also higher in students of higher socioeconomical status than the students of lower status (p < 0.05). A statistically significant relationship was not determined between the nasal carriage and the risk factors (history of hospitalisation or surgical operation in the previous one year, use of antibiotics or history of skin/soft tissue infection in the last 6 months, presence of children < 15-years-old in the family, presence of healthcare workers in the same house, living in a crowded house). Penicillin and erythromycin resistance was found in 93.6% and 14.2% of MSSA strains, respectively. No resistance was detected against ciprofloxacin, co-trimoxazole, linezolid and vancomycin. There was a statistically significant difference between erythromycin resistance and antibiotic use within the last six months and the number of family members (p < 0.05). In conclusion, current treatment regimens still seem to be affective and safe for the empirical treatment of community-acquired S. aureus infections. Although CA-MRSA infections seem not to be a serious threat in our region yet, it is essential to carry out prevalence studies in the different populations of the community.
本研究旨在评估土耳其马尼萨学生中社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）的携带率及危险因素。共有2015名学生（1012名来自高中最后阶段，1003名来自小学第一阶段）纳入本研究。所有学生均无鼻腔MRSA携带情况。甲氧西林敏感金黄色葡萄球菌（MSSA）定植率为14.7%（296/2015）。小学生中MSSA鼻腔携带率（17.8%）显著高于高中生（11.6%）（p<0.001）。社会经济地位较高的学生中MSSA携带率也高于地位较低的学生（p<0.05）。未确定鼻腔携带与危险因素（过去一年的住院或手术史、过去6个月使用抗生素或皮肤/软组织感染史、家中有<15岁儿童、家中有医护人员、居住在拥挤的房屋中）之间存在统计学显著关系。分别在93.6%和14.2%的MSSA菌株中发现青霉素和红霉素耐药。未检测到对环丙沙星、复方新诺明、利奈唑胺和万古霉素的耐药。红霉素耐药与过去六个月内抗生素使用及家庭成员数量之间存在统计学显著差异（p<0.05）。总之，目前的治疗方案对于社区获得性金黄色葡萄球菌感染的经验性治疗似乎仍然有效且安全。尽管CA-MRSA感染在我们地区似乎尚未构成严重威胁，但在社区的不同人群中开展患病率研究至关重要。
