Stefan C, Dragomir L, Dumitrică Diana Melinte, Ursaciuc C, Dobre Maria, Surcel Mihaela
Clinica de Oftalmologie, Spitalul Clinic de Urgenţă Militar Central.
Oftalmologia. 2008;52(3):110-2.
To emphasize the correlation between TGF beta2 and primary open angle glaucoma (POAG).
Observational clinical study on two groups of patients: group I--17 patients with POAG who need surgical approach and group II--16 patients without glaucoma. The groups were homogeneous regarding age and sex. The exclusion criteria were any associated systemic pathology. The concentration of TGF beta2 in the aqueous humor of each patient of both groups was measured by ELISA method.
After the comparative analysis we observed that TGF beta2 was more increased in patients with POAG than in patients without the disease. The changes of trabecular extra cellular matrix are induced by many factors. TGF beta2 is a special cytokine witch is believed to increase the fibronectin concentration in the trabecular meshwork and alter the extra cellular matrix turn-over with a final profibrotic effect.
强调转化生长因子β2（TGF beta2）与原发性开角型青光眼（POAG）之间的相关性。
对两组患者进行观察性临床研究：第一组——17例需要手术治疗的POAG患者，第二组——16例无青光眼患者。两组在年龄和性别方面具有同质性。排除标准为任何相关的全身性病变。采用酶联免疫吸附测定（ELISA）法测量两组每位患者房水中TGF beta2的浓度。
经过对比分析，我们观察到POAG患者房水中的TGF beta2升高程度高于未患该疾病的患者。小梁细胞外基质的变化由多种因素诱导。TGF beta2是一种特殊的细胞因子，据信它会增加小梁网中纤连蛋白的浓度，并改变细胞外基质的周转，最终产生促纤维化作用。
