原发性开角型青光眼患者房水中促红细胞生成素水平

Aqueous humor erythropoietin levels in patients with primary open-angle glaucoma.

作者信息

Cumurcu Tongabay, Bulut Yunus, Demir Helin Deniz, Yenisehirli Gulgun

机构信息

Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.

出版信息

J Glaucoma. 2007 Dec;16(8):645-8. doi: 10.1097/IJG.0b013e31804a5eb3.

DOI:10.1097/IJG.0b013e31804a5eb3

PMID:18091448

Abstract

PURPOSE

To evaluate the levels of erythropoietin (EPO) in the aqueous humor in eyes with primary open-angle glaucoma (POAG) and without glaucoma.

METHODS

Levels of EPO were measured using a sandwich enzyme-linked immunosorbent assay kit in aqueous humor aspirates taken during anterior segment surgery from 45 patients, of whom 20 had POAG and 25 had senile cataract only.

RESULTS

The mean aqueous humor EPO concentration in eyes with POAG (10.91+/-4.32 mU/mL) was significantly higher than that from eyes with cataract (8.24+/-1.77 mU/mL, P=0.008). There was no significant difference between the serum EPO concentrations of POAG (26.46+/-10.36 mU/mL) and the control group (24.50+/-7.59 mU/mL, P=0.468). There was no correlation (P=0.165) between the EPO aqueous humor concentration and the EPO serum concentration while there was no correlation between the EPO aqueous humor concentration and the EPO serum concentration in the control group (P=0.819).

CONCLUSIONS

The aqueous humor EPO level is increased in eyes with POAG.

摘要

目的

评估原发性开角型青光眼（POAG）患者和非青光眼患者房水中促红细胞生成素（EPO）的水平。

方法

采用夹心酶联免疫吸附测定试剂盒，对45例患者眼前节手术时采集的房水抽吸物中的EPO水平进行检测，其中20例患有POAG，25例仅患有老年性白内障。

结果

POAG患者房水中EPO的平均浓度（10.91±4.32 mU/mL）显著高于白内障患者（8.24±1.77 mU/mL，P = 0.008）。POAG患者血清EPO浓度（26.46±10.36 mU/mL）与对照组（24.50±7.59 mU/mL，P = 0.468）之间无显著差异。房水中EPO浓度与血清EPO浓度之间无相关性（P = 0.165），对照组房水中EPO浓度与血清EPO浓度之间也无相关性（P = 0.819）。