Ayenew Zelalem, Puri Vibha, Kumar Lokesh, Bansal Arvind K
Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab, India.
Recent Pat Drug Deliv Formul. 2009 Jan;3(1):26-39. doi: 10.2174/187221109787158364.
According to the year 2003 survey of pediatricians by the American Association of Pediatrics, unpleasant taste was the biggest barrier for completing treatment in pediatrics. The field of taste masking of active pharmaceutical ingredients (API) has been continuously evolving with varied technologies and new excipients. The article reviews the trends in taste masking technologies by studying the current state of the art patent database for the span of year 1997 to 2007. The worldwide database of European patent office (http://ep.espacenet.com) was employed to collect the patents and patent applications. It also discusses the possible reasons for the change of preferences in the taste masking technologies with time. The prime factors critical to the selection of an optimal taste masking technique such as the extent of drug bitterness, solubility, particle characteristics, dosage form and dose are briefly discussed.
根据美国儿科学会2003年对儿科医生的调查，不良味道是儿科治疗完成过程中的最大障碍。活性药物成分（API）掩味领域一直在随着各种技术和新型辅料不断发展。本文通过研究1997年至2007年期间的现有技术专利数据库，回顾了掩味技术的发展趋势。利用欧洲专利局的全球数据库（http://ep.espacenet.com）收集专利和专利申请。本文还讨论了掩味技术偏好随时间变化的可能原因。简要讨论了选择最佳掩味技术的关键主要因素，如药物苦味程度、溶解度、颗粒特性、剂型和剂量。
