急性肝衰竭的凝血功能障碍
Coagulopathy of acute liver failure.
作者信息
Munoz Santiago J, Stravitz R Todd, Gabriel Don A
机构信息
University of Pennsylvania, School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA; PENN Presbyterian Medical Center, 38th and Market Streets, MOB 220, Philadelphia, PA 19104, USA.
Section of Hepatology, Hume-Lee Transplant Center, PO Box 980341, Virginia Commonwealth University, Richmond, VA 23298-0341, USA.
出版信息
Clin Liver Dis. 2009 Feb;13(1):95-107. doi: 10.1016/j.cld.2008.10.001.
Coagulopathy is an essential component of the acute liver failure (ALF) syndrome and reflects the central role of liver function in hemostasis. ALF is a syndrome characterized by the development of hepatic encephalopathy and coagulopathy within 24 weeks of the onset of acute liver disease. Coagulopathy in this setting is a useful prognostic tool in ALF and a dynamic indicator of the hepatic function. If severe, it can be associated with bleeding and is commonly a major obstacle to the performance of invasive procedures in patients with ALF. This review focuses on the epidemiology, pathophysiology, presentation, evaluation, and management of coagulopathy in ALF.
凝血功能障碍是急性肝衰竭（ALF）综合征的重要组成部分，反映了肝功能在止血过程中的核心作用。ALF是一种在急性肝病发病后24周内出现肝性脑病和凝血功能障碍的综合征。这种情况下的凝血功能障碍是ALF中一种有用的预后工具，也是肝功能的动态指标。如果严重，它可能与出血相关，并且通常是ALF患者进行侵入性操作的主要障碍。本综述重点关注ALF中凝血功能障碍的流行病学、病理生理学、表现、评估和管理。
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