van den Biggelaar Anita H J, Richmond Peter C, Pomat William S, Phuanukoonnon Suparat, Nadal-Sims Marie A, Devitt Catherine J, Siba Peter M, Lehmann Deborah, Holt Patrick G
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, WA 6872, Australia.
Vaccine. 2009 Feb 25;27(9):1340-7. doi: 10.1016/j.vaccine.2008.12.046. Epub 2009 Jan 14.
The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
在一群巴布亚新几内亚新生儿中，研究了7价肺炎球菌结合疫苗（7vPCV）新生儿免疫对T细胞记忆发育和整体免疫成熟的影响。与仅在1和2月龄接种7vPCV相比，新生儿7vPCV初免（随后在1和2月龄各接种一剂）与对CRM(197)的Th2细胞因子反应增强有关，但Th1细胞因子反应无增强。所有组中对非7vPCV疫苗抗原的T细胞反应相似，但与对照组相比，接种7vPCV的组中TLR介导的IL-6和IL-10反应增强。新生儿接种7vPCV可引发T细胞反应，使其向Th2极化，且对其他T细胞反应无旁观者效应。
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