Sadeh M, Blatt I, Martonovits G, Karni A, Goldhammer Y
Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Epilepsia. 1991 Sep-Oct;32(5):712-5. doi: 10.1111/j.1528-1157.1991.tb04714.x.
We report a 16-year-old girl with acute intermittent porphyria who had abdominal pain, generalized tonic-clonic and simple partial seizures, and inappropriate antidiuretic hormone secretion. Because most antiepileptic drugs are contraindicated in porphyria, she was treated with magnesium sulfate i.v. Soon after starting treatment, seizures stopped, returned, and then again responded in several trials with discontinuation and reinstitution of i.v. magnesium sulfate. Our experience encourages the use of magnesium sulfate for treatment of seizures in patients with porphyria.
我们报告了一名16岁患急性间歇性卟啉病的女孩，她有腹痛、全身性强直阵挛发作和单纯部分性发作，以及抗利尿激素分泌异常。由于大多数抗癫痫药物在卟啉病中是禁忌的，她接受了静脉注射硫酸镁治疗。开始治疗后不久，癫痫发作停止，之后又复发，在几次停止和重新静脉注射硫酸镁的试验中再次得到缓解。我们的经验鼓励使用硫酸镁治疗卟啉病患者的癫痫发作。
