Li HaoWen, Li JinZhi, Zhao GuoPing, Wang Ying
Shanghai Institute of Immunology, Institute of Medical Science, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Sci China C Life Sci. 2009 Jan;52(1):43-9. doi: 10.1007/s11427-009-0006-7. Epub 2009 Jan 19.
This review updates the current status of immunology research under the influence of genomics, both conceptually and technologically. It particularly highlights the advantages of employing the high-throughput and large-scale technology, the large genomic database, and bioinformatic power in the immunology research. The fast development in the fields of basic immunology, clinical immunology (tumor and infectious immunology) and vaccine designing is illustrated with respect to the successful usage of genomic strategy. We also speculate the future research directions of immunology in the era of genomics and post-genomics.
本综述从概念和技术两方面更新了基因组学影响下的免疫学研究现状。它特别强调了在免疫学研究中采用高通量大规模技术、大型基因组数据库和生物信息学能力的优势。通过基因组策略的成功应用,阐述了基础免疫学、临床免疫学(肿瘤和感染免疫学)以及疫苗设计领域的快速发展。我们还推测了基因组学和后基因组学时代免疫学的未来研究方向。