Backus Barbra E, Verburg Frederik A, Romijn R Leo, Konijnenberg Mark W, Beekman Freek J, Verzijlbergen J Fred
Department of Nuclear Medicine, St. Antonius Hospital, Koekoekslaan 1, Postbus 2500, 3430 EM, Nieuwegein, The Netherlands.
J Nucl Cardiol. 2009 Jan-Feb;16(1):97-104. doi: 10.1007/s12350-008-9011-7. Epub 2009 Jan 20.
To define the physical and clinical reproducibility of (201)Tl myocardial perfusion SPECT (MPS), this study assesses the variation between two repeated rest (201)Tl MPS with repositioning only, with a two-hour time interval and with phantom measurements as a reference.
Three anthropomorphic thorax phantoms were filled with (201)Tl. For each phantom five repeated (201)Tl MPS were obtained. In addition, in 20 patients repeated (201)Tl rest-MPS and in 26 patients early and delayed (201)Tl rest-MPS were performed. Quantitative analysis was done using MunichHeart. Statistical methods were used to calculate variability. Visual analysis was performed by 2 independent observers.
The average variation between repeated phantom MPS was 0.5% (95% confidence interval (CI): -0.4% to 1.4%). For patient scans this was -5.0% (95% CI: -2.5% to -7.5%) and between early and delayed (201)Tl MPS -15.5% (95% CI: -11.7% to -19.3%). Visual assessment revealed no clinical significant differences between rest (201)Tl and repeated or delayed (201)Tl MPS.
Repositioning in phantom (201)Tl MPS does not cause significant variation. Repeated (201)Tl MPS in patients shows 5.0% decrease of (201)Tl in 30 minutes, which increases to 15% during a two-hour time interval without quantitative or visual regional differences. This decrease indicates a time-related washout of (201)Tl, but does not change clinical diagnosis.
为了确定铊-201 心肌灌注单光子发射计算机断层扫描（MPS）的物理和临床可重复性，本研究评估了仅重新定位、间隔两小时的两次重复静息铊-201 MPS 之间的差异，并以体模测量作为参考。
三个模拟人体胸部体模填充铊-201。对每个体模进行五次重复铊-201 MPS 检查。此外，对 20 名患者进行了重复静息铊-201 MPS 检查，对 26 名患者进行了早期和延迟静息铊-201 MPS 检查。使用 MunichHeart 进行定量分析。采用统计方法计算变异性。由两名独立观察者进行视觉分析。
重复体模 MPS 之间的平均差异为 0.5%（95%置信区间（CI）：-0.4%至 1.4%）。患者扫描的差异为-5.0%（95%CI：-2.5%至-7.5%），早期和延迟铊-201 MPS 之间的差异为-15.5%（95%CI：-11.7%至-19.3%）。视觉评估显示静息铊-201 与重复或延迟铊-201 MPS 之间无临床显著差异。
体模铊-201 MPS 重新定位不会引起显著差异。患者重复铊-201 MPS 显示 30 分钟内铊-201 减少 5.0%，在两小时时间间隔内增加到 15%，且无定量或视觉区域差异。这种减少表明铊-201 存在与时间相关的洗脱，但不改变临床诊断。
