用于感染艾滋病毒的男同性恋者甲基苯丙胺使用问题的安非他明（莫达非尼）加认知行为疗法：一项试点研究。
Provigil (modafinil) plus cognitive behavioral therapy for methamphetamine use in HIV+ gay men: a pilot study.
作者信息
McElhiney Martin C, Rabkin Judith G, Rabkin Richard, Nunes Edward V
机构信息
Therapeutics, New York State Psychiatric Institute, New York, New York, USA.
出版信息
Am J Drug Alcohol Abuse. 2009;35(1):34-7. doi: 10.1080/00952990802342907.
OBJECTIVES
To evaluate the efficacy of modafinil combined with cognitive behavioral therapy (CBT) for treatment of methamphetamine (MA) dependence among HIV+ gay men.
METHODS
In a single blind trial, modafinil was administered for 12 weeks, followed by a 4-week placebo phase. CBT was conducted for 18 sessions over the 16-week study. Primary outcome measures were self-reported use of days per week plus urine toxicology assays. Additional measures included the Beck Depression Inventory, Cravings Scale, and O/C Crystal Use Scale. Response was defined as > 50% decline in days used per week. Thirteen patients were enrolled over an 18-month period.
RESULTS
Ten patients (77%) completed the trial, although two discontinued modafinil due to side effects. Six of the ten study completers reduced their MA use by > 50%.
CONCLUSIONS
These preliminary results suggest good retention using combined medication and psychotherapy, and support further examination of modafinil and CBT in double-blind placebo controlled trials.
目的
评估莫达非尼联合认知行为疗法（CBT）治疗HIV阳性男同性恋者甲基苯丙胺（MA）依赖的疗效。
方法
在一项单盲试验中，莫达非尼给药12周，随后是4周的安慰剂阶段。在为期16周的研究中进行了18次CBT治疗。主要结局指标是自我报告的每周使用天数以及尿液毒理学检测。其他指标包括贝克抑郁量表、渴望量表和O/C晶体使用量表。反应定义为每周使用天数下降>50%。在18个月的时间里招募了13名患者。
结果
10名患者（77%）完成了试验，尽管有两名患者因副作用停止使用莫达非尼。10名完成研究的患者中有6名将其MA使用量减少了>50%。
结论
这些初步结果表明联合药物治疗和心理治疗具有良好的保留率，并支持在双盲安慰剂对照试验中进一步研究莫达非尼和CBT。
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