Naseri Iman, Jerris Robert C, Sobol Steven E
Departments of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Arch Otolaryngol Head Neck Surg. 2009 Jan;135(1):14-6. doi: 10.1001/archoto.2008.511.
To evaluate the epidemiologic manifestations of pediatric Staphylococcus aureus head and neck infections nationwide and to identify possible trends in the antibiotic drug susceptibility of S aureus during a 6-year period.
Retrospective review of microbiologic data from a peer-reviewed national database.
More than 300 hospitals nationwide.
All pediatric patients with head and neck infections involving S aureus.
Anatomic sites were divided into oropharynx/neck, sinonasal, and otologic infection categories. Demographic and antimicrobial drug susceptibility patterns were reviewed.
A total of 21,009 pediatric head and neck S aureus infections that occurred between January 2001 and December 31, 2006 were gathered from the database. Predominance was observed in the oropharyngeal/neck category (60.3%). For all sites, the mean patient age was 6.7 years (range, 0-18 years), with a 51.7% male predominance. There was a high occurrence in the North East Central region of the United States. Overall, methicillin-resistant S aureus was seen in 21.6% of all patient isolates (n = 4534), with rates of 11.8%, 12.5%, 18.1%, 27.2%, 25.5%, and 28.1% for 2001 through 2006, respectively. This represents a 16.3% increase in methicillin-resistant S aureus during these 6 years for all pediatric head and neck S aureus infections.
There is an alarming nationwide increase in the prevalence of pediatric methicillin-resistant S aureus head and neck infections. Disparities in the treatment of various head and neck infections nationwide may contribute to the regional differences in the prevalence of such infections. Judicious use of antibiotic agents and increased effectiveness in diagnosis and treatment are warranted to reduce further antimicrobial drug resistance in pediatric head and neck infections.
评估全国范围内儿童金黄色葡萄球菌头颈部感染的流行病学表现，并确定6年间金黄色葡萄球菌抗生素药敏的可能趋势。
对来自一个同行评审的全国性数据库的微生物学数据进行回顾性分析。
全国300多家医院。
所有涉及金黄色葡萄球菌的儿童头颈部感染患者。
解剖部位分为口咽/颈部、鼻窦和耳部感染类别。回顾人口统计学和抗菌药物药敏模式。
从数据库中收集了2001年1月1日至2006年12月31日期间发生的总共21009例儿童头颈部金黄色葡萄球菌感染病例。口咽/颈部类别占主导（60.3%）。所有部位的患者平均年龄为6.7岁（范围0至18岁），男性占51.7%。美国东北部地区发病率较高。总体而言，所有患者分离株中21.6%（n = 4534）为耐甲氧西林金黄色葡萄球菌，2001年至2006年的发生率分别为11.8%、12.5%、18.1%、27.2%、25.5%和28.1%。这表明在这6年中，所有儿童头颈部金黄色葡萄球菌感染中耐甲氧西林金黄色葡萄球菌增加了16.3%。
全国范围内儿童耐甲氧西林金黄色葡萄球菌头颈部感染的患病率惊人地增加。全国不同头颈部感染治疗的差异可能导致此类感染患病率的区域差异。明智地使用抗生素并提高诊断和治疗的有效性，对于减少儿童头颈部感染中进一步的抗菌药物耐药性是必要的。
