Venkadesh S, Mandal P K, Gautham N
Centre for Advanced Study in Crystallography and Biophysics, University of Madras, Chennai, India.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jan 1;65(Pt 1):8-13. doi: 10.1107/S1744309108037706. Epub 2008 Dec 25.
The crystal structure of d(CACACG).d(CGTGTG) was solved to a resolution of 2.05 A in space group P2(1). The duplex assumes the left-handed Z-DNA structure. The presence of two A.T base pairs in the hexamer does not greatly affect the conformation. The most significant changes compared with the regular structure of Z-DNA are in the values of twist in the central portion of the helix. This variation, as well as others in the values of roll, inclination etc., follow the pattern observed previously in the structure of d(CGCACG).d(CGTGCG).
d(CACACG).d(CGTGTG)的晶体结构在空间群P2(1)中解析到2.05 Å的分辨率。该双链体呈现左手Z-DNA结构。六聚体中两个A.T碱基对的存在对构象影响不大。与Z-DNA的规则结构相比,最显著的变化在于螺旋中心部分的扭转值。这种变化以及滚动、倾斜等值的其他变化,遵循了先前在d(CGCACG).d(CGTGCG)结构中观察到的模式。