成体脑室周围神经干细胞的身份危机：脑室下区星形胶质细胞、室管膜细胞，还是两者皆是？

Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both?

作者信息

Chojnacki Andrew K, Mak Gloria K, Weiss Samuel

机构信息

Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, University of Calgary, Faculty of Medicine, Calgary, Alberta, T2N 4N1, Canada.

出版信息

Nat Rev Neurosci. 2009 Feb;10(2):153-63. doi: 10.1038/nrn2571.

DOI:10.1038/nrn2571

PMID:19153578

Abstract

A population of neural stem cells (NSCs) resides adjacent to the lateral ventricles in the adult mammalian brain. Despite knowledge of their existence since the early 1990s, their identity remains controversial, with evidence suggesting that they may be ependymal cells, glial fibrillary acidic protein (GFAP)-expressing subventricular zone (SVZ) cells or several distinct NSC populations. This issue has major implications for the therapeutic use of NSCs as well as for the study and treatment of brain cancers. Recent studies have both shed light on the issue and added to the controversy.

摘要

在成年哺乳动物大脑中，一群神经干细胞（NSCs）位于侧脑室附近。尽管自20世纪90年代初就已知道它们的存在，但其身份仍存在争议，有证据表明它们可能是室管膜细胞、表达胶质纤维酸性蛋白（GFAP）的脑室下区（SVZ）细胞或几个不同的神经干细胞群体。这个问题对神经干细胞的治疗应用以及脑癌的研究和治疗都有重大影响。最近的研究既为这个问题带来了启示，也增加了争议。