Charman W Neil, Radhakrishnan Hema
Faculty of Life Sciences, University of Manchester, Manchester, UK.
Ophthalmic Physiol Opt. 2009 Jan;29(1):72-9. doi: 10.1111/j.1475-1313.2008.00611.x.
Concurrent measurements of steady-state accommodation response/stimulus curves and of pupil diameter were made in groups (n = 20) of young, adult myopes [age (mean +/- SD) 23.1 +/- 4.5 years, mean-sphere error (MSE) -3.06 +/- 2.35 D, range -0.60 to -8.54 D] and emmetropes (mean age 25.3 +/- 5.7 years, mean MSE -0.07 +/- 0.26 D, range -0.50 to +0.50 D). The aim of this study was to explore the possibilities that pupil diameters with relaxed accommodation were larger, and that accommodative miosis was weaker, in the myopic group. Such behaviour would lead to relatively greater degradation of the retinal images in the myopic group, even though aberrations at constant pupil diameter and dioptric accommodative lags in the two groups were the same: this might result in excessive axial growth and further myopia development. No evidence for any systematic refractive dependence of pupillary characteristics or accommodative responses was found. Interestingly, those subjects whose response/stimulus curves had a higher slope tended to display greater accommodative miosis, irrespective of their refractive error.
对年轻的成年近视者（n = 20）[年龄（均值±标准差）23.1±4.5岁，平均球镜度数（MSE）-3.06±2.35 D，范围-0.60至-8.54 D]和正视者（平均年龄25.3±5.7岁，平均MSE -0.07±0.26 D，范围-0.50至+0.50 D）进行了稳态调节反应/刺激曲线以及瞳孔直径的同步测量。本研究的目的是探讨近视组中放松调节时瞳孔直径更大以及调节性瞳孔缩小较弱的可能性。这种行为将导致近视组视网膜图像的相对更大程度退化，尽管两组在恒定瞳孔直径下的像差和屈光性调节滞后是相同的：这可能导致眼轴过度生长和近视进一步发展。未发现瞳孔特征或调节反应存在任何系统性屈光依赖性的证据。有趣的是，那些反应/刺激曲线斜率较高的受试者往往表现出更大的调节性瞳孔缩小，无论其屈光不正情况如何。
