器官发生所需的非转铁蛋白依赖性铁转运系统。

A Tf-independent iron transport system required for organogenesis.

作者信息

Troadec Marie-Berengere, Ward Diane M, Kaplan Jerry

机构信息

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

出版信息

Dev Cell. 2009 Jan;16(1):3-4. doi: 10.1016/j.devcel.2008.12.013.

DOI:10.1016/j.devcel.2008.12.013

PMID:19154711

Abstract

Cells require iron as a cofactor for proteins that are essential for growth. While delivery of iron to cells by transferrin is well known, Li et al. in this issue of Developmental Cell show that ferritin, through its binding to the cell surface Scara5 receptor, can also deliver iron to cells, permitting kidney organogenesis.

摘要

细胞需要铁作为对生长至关重要的蛋白质的辅助因子。虽然转铁蛋白将铁输送到细胞的过程已为人熟知，但李等人在本期《发育细胞》中表明，铁蛋白通过与细胞表面的Scara5受体结合，也可以将铁输送到细胞中，从而促进肾脏器官的形成。