Lin Chien-Yuan, Lin Ming-Huang, Cheung Wai-Mui, Lin Teng-Nan, Chen Jyh-Horng, Chang Chen
Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Neuroimage. 2009 Apr 15;45(3):824-31. doi: 10.1016/j.neuroimage.2008.12.030. Epub 2008 Dec 29.
This study proposed a novel methodology for depicting cerebral small vessels including veins, arterioles, and venules, called 3DDeltaR(2)-mMRA (three-dimensional, steady-state DeltaR(2)-based, and flow-independent microscopic magnetic resonance angiography). The DeltaR(2) map calculated by a fast spin-echo imaging technique before and after the injection of an iron-oxide contrast agent was used to delineate the relative cerebral blood volume, primarily to microvasculature. The proposed 3DDeltaR(2)-mMRA method, which employs 3D reconstruction techniques, can simultaneously provide high-resolution 3D information on the cerebral anatomy, in vivo microvascular architecture, and hemodynamic response, which can be used to evaluate pathological microvascular changes over time in cerebromicrovascular disease. Since spin-echo-based DeltaR(2) imaging was applied, the inflow effects, susceptibility artifacts, and the overestimation of vessel size in brain were reduced. A well-defined three-vessel occlusion model in the rat was performed to evaluate the capability of the proposed method in evaluating alterations to the microvasculature.
本研究提出了一种用于描绘脑小血管（包括静脉、小动脉和小静脉）的新方法，称为3DDeltaR(2)-mMRA（三维、基于稳态DeltaR(2)且与血流无关的微观磁共振血管造影）。通过快速自旋回波成像技术在注射氧化铁造影剂前后计算得到的DeltaR(2)图，用于描绘相对脑血容量，主要针对微血管系统。所提出的3DDeltaR(2)-mMRA方法采用三维重建技术，能够同时提供关于脑解剖结构、体内微血管结构和血流动力学反应的高分辨率三维信息，可用于评估脑微血管疾病中随时间变化的病理性微血管改变。由于应用了基于自旋回波的DeltaR(2)成像，减少了脑内的流入效应、磁化率伪影以及血管大小的高估。在大鼠中构建了一个明确的三血管闭塞模型，以评估所提方法评估微血管系统改变的能力。
