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慢性心力衰竭患者桑拿浴的安全性、可接受性及生理效应:一项初步报告

Safety, acceptance, and physiologic effects of sauna bathing in people with chronic heart failure: a pilot report.

作者信息

Basford Jeffrey R, Oh Jae K, Allison Thomas G, Sheffield Charles G, Manahan Barbara G, Hodge David O, Tajik A Jamil, Rodeheffer Richard J, Tei Chuwa

机构信息

Department of Physical Medicine and Rehabilitation, Mayo Clinic Rochester, Rochester, MN, USA.

出版信息

Arch Phys Med Rehabil. 2009 Jan;90(1):173-7. doi: 10.1016/j.apmr.2008.06.029.

Abstract

OBJECTIVES

To perform a pilot study and make a preliminary assessment of the safety and acceptance of supervised sauna bathing at moderate temperatures in people with chronic heart failure (CHF). Secondary measures included its impact on exercise tolerance and neuroendocrine concentrations.

DESIGN

Randomized, controlled, cross-over trial.

SETTING

Physical medicine and rehabilitation clinic.

PARTICIPANTS

Six men and 3 women (age, 62-87y) with New York Heart Association Class III and IV CHF.

INTERVENTIONS

Subjects were randomized into 2 groups and told to maintain their normal medication and activity regimens. One group then began a 3-times-a-week, 4-week sauna bathing program at 60+/-1 degrees C while the other continued with their usual activities and medications. Assignments were then reversed. Sessions were 15 minutes in length but were prolonged an additional 5 minutes for oral temperature increases less than 1.0 degrees C.

MAIN OUTCOME MEASURES

Patient acceptance, Minnesota Living With Heart Failure Questionnaire (MLWHFQ) scores; treadmill exercise duration and plasma adrenaline, noradrenalin, aldosterone, atrial naturectic factor, adrenomedulin, and endothelin.

RESULTS

Sauna bathing was well tolerated and no adverse effects were reported. Improvements in MLWHFQ scores and treadmill endurance did not achieve statistical significance on a between-group basis but were more marked after the sauna than during the control phase. Neuroendocrine concentrations showed no clear effect of sauna treatment with a between-group statistically significant difference (P=.049) found only in the case of noradrenalin's 24% decrease.

CONCLUSIONS

Sauna bathing under the moderate and supervised conditions of this study appears to be well tolerated and may be safe for people with CHF. More research is needed to further evaluate the safety and potential benefits of this approach.

摘要

目的

进行一项初步研究,并对慢性心力衰竭(CHF)患者在适度温度下进行有监督的桑拿浴的安全性和接受度进行初步评估。次要指标包括其对运动耐力和神经内分泌浓度的影响。

设计

随机、对照、交叉试验。

地点

物理医学与康复诊所。

参与者

6名男性和3名女性(年龄62 - 87岁),纽约心脏协会心功能分级为III级和IV级的CHF患者。

干预措施

将受试者随机分为两组,并告知他们维持正常的药物治疗和活动方案。一组开始在60±1摄氏度下每周进行3次、为期4周的桑拿浴计划,而另一组继续其常规活动和药物治疗。然后两组任务互换。每次桑拿浴时长为15分钟,但如果口腔温度升高低于1.0摄氏度,则延长5分钟。

主要观察指标

患者接受度、明尼苏达心力衰竭生活问卷(MLWHFQ)评分;跑步机运动时长以及血浆肾上腺素、去甲肾上腺素、醛固酮、心房利钠因子、肾上腺髓质素和内皮素。

结果

桑拿浴耐受性良好,未报告不良反应。MLWHFQ评分和跑步机耐力的改善在组间比较上未达到统计学显著性,但在桑拿浴后比对照阶段更明显。神经内分泌浓度方面,桑拿浴治疗未显示出明显效果,仅在去甲肾上腺素降低24%的情况下组间存在统计学显著性差异(P = 0.049)。

结论

在本研究的适度且有监督的条件下,桑拿浴似乎耐受性良好,对CHF患者可能是安全的。需要更多研究来进一步评估这种方法的安全性和潜在益处。

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