二甲双胍及二甲双胍联合醋酸环丙孕酮对多囊卵巢综合征女性的代谢和内分泌影响
Metabolic and endocrine effects of metformin and metformin plus cyclic medroxyprogesterone acetate in women with polycystic ovary syndrome.
作者信息
Haydardedeoglu Bulent, Simsek Erhan, Kilicdag Esra B, Bagis Tayfun
机构信息
Baskent University Faculty of Medicine, Department of Obstetrics and Gynecology, Adana, Turkey.
出版信息
Int J Gynaecol Obstet. 2009 Apr;105(1):32-5. doi: 10.1016/j.ijgo.2008.11.039. Epub 2009 Jan 19.
OBJECTIVE
To evaluate the metabolic and endocrine effects of treatment with cyclic medroxyprogesterone acetate (MPA) plus metformin compared with metformin alone in women with PCOS.
METHODS
In this prospective randomized study of women with PCOS, 20 women received 850 mg of metformin twice a day, and 20 women received 850 mg of metformin plus 5 mg of MPA twice a day. Body mass index, hormonal and lipid blood profiles, homocysteine blood level, and insulin sensitivities assessed by homeostasis model assessment (HOMA) were recorded at baseline and at 3 months.
RESULTS
Total cholesterol levels decreased in the metformin plus MPA group (P=0.002) but did not change significantly in the metformin group (P=0.159). While homocysteine levels remained unchanged in the metformin plus MPA group, they increased significantly in the metformin group (P=0.002).
CONCLUSION
There were no adverse effects of short-term cyclic MPA plus metformin treatment on metabolic parameters or insulin resistance in patients with PCOS over a 3-month treatment period.
目的
评估醋酸环丙孕酮（MPA）联合二甲双胍治疗与单纯二甲双胍治疗对多囊卵巢综合征（PCOS）女性的代谢和内分泌影响。
方法
在这项针对PCOS女性的前瞻性随机研究中，20名女性每天两次服用850毫克二甲双胍，20名女性每天两次服用850毫克二甲双胍加5毫克MPA。在基线和3个月时记录体重指数、激素和血脂谱、血液中同型半胱氨酸水平以及通过稳态模型评估（HOMA）评估的胰岛素敏感性。
结果
二甲双胍加MPA组的总胆固醇水平下降（P = 0.002），而二甲双胍组无显著变化（P = 0.159）。二甲双胍加MPA组的同型半胱氨酸水平保持不变，而二甲双胍组显著升高（P = 0.002）。
结论
在3个月的治疗期内，短期周期性MPA联合二甲双胍治疗对PCOS患者的代谢参数或胰岛素抵抗无不良影响。
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