内源性产生的白细胞介素-4非冗余性地刺激CD8 + T细胞增殖。

Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation.

作者信息

Morris Suzanne C, Heidorn Stephanie M, Herbert De'Broski R, Perkins Charles, Hildeman David A, Khodoun Marat V, Finkelman Fred D

机构信息

Research Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA.

出版信息

J Immunol. 2009 Feb 1;182(3):1429-38. doi: 10.4049/jimmunol.182.3.1429.

T cell proliferation and survival are regulated by the cytokine receptor common gamma-chain-associated cytokines IL-2, IL-7, and IL-15, while IL-4, another gamma-chain-associated cytokine, is thought to primarily affect T cell quality rather than quantity. In contrast, our experiments reveal that endogenously produced IL-4 is a direct, nonredundant, and potent stimulator of CD8(+) T cell proliferation in Ag- and pathogen-induced CD8(+) T cell responses. These stimulatory effects of IL-4 are observed in both BALB/c and C57BL/6 mice and activate both naive and memory/activated phenotype CD8(+) T cells, although the former are stimulated less than are the latter. IL-4 effects are IL-7- and IL-15-independent, but MHC class I-dependent stimulation appears to be required for the mitogenic effect of IL-4 on naive phenotype CD8(+) T cells. Thus, endogenously produced IL-4 is an important regulator of quantitative as well as qualitative aspects of T cell immunity.

T细胞的增殖和存活受细胞因子受体共同γ链相关细胞因子IL-2、IL-7和IL-15的调节，而另一种γ链相关细胞因子IL-4则被认为主要影响T细胞的质量而非数量。相比之下，我们的实验表明，内源性产生的IL-4在抗原和病原体诱导的CD8(+) T细胞反应中是CD8(+) T细胞增殖的直接、非冗余且有效的刺激因子。在BALB/c和C57BL/6小鼠中均观察到IL-4的这些刺激作用，并且它能激活初始型和记忆/活化表型的CD8(+) T细胞，尽管前者受到的刺激小于后者。IL-4的作用不依赖IL-7和IL-15，但IL-4对初始表型CD8(+) T细胞的促有丝分裂作用似乎需要MHC I类依赖性刺激。因此，内源性产生的IL-4是T细胞免疫在数量和质量方面的重要调节因子。