Shields Carol L, Salazar Pedro F, Mashayekhi Arman, Shields Jerry A
The Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Ophthalmology. 2009 Mar;116(3):529-35. doi: 10.1016/j.ophtha.2008.10.015. Epub 2009 Jan 20.
To evaluate the clinical features and outcomes of eyes with peripheral exudative hemorrhagic chorioretinopathy (PEHCR) simulating choroidal melanoma.
Noncomparative case series.
A total of 173 eyes in 146 patients.
Retrospective chart review.
Clinical features and outcome.
All cases were referred for possible choroidal melanoma. The mean patient age was 80 years, 145 (99%) were Caucasian, and 98 (67%) were female. The main lesion had a mean diameter of 10 mm and mean thickness of 3 mm. The lesion was located temporally in 103 eyes (77%), involved 1 or 2 quadrants in 123 eyes (92%), and was located between the equator and the ora serrata in 119 eyes (89%). Features included subretinal hemorrhage in 134 eyes (78%), retinal exudation in 37 eyes (21%), retinal pigment epithelial (RPE) detachment in 48 eyes (28%), and sub-RPE hemorrhage in 45 eyes (26%). Peripheral RPE alterations or drusen were found in 120 ipsilateral eyes (69%) and 73 contralateral eyes (42%). Macular RPE alterations, drusen, or choroidal neovascularization was found in 83 ipsilateral eyes (48%) and 97 contralateral eyes (56%). After observation (mean 15 months), lesion regression or stability was found in 80 eyes (89%) and progression was found in 10 eyes (11%).
PEHCR is a hemorrhagic retinal degenerative process that simulates choroidal melanoma.
评估模拟脉络膜黑色素瘤的周边渗出性出血性脉络膜视网膜病变(PEHCR)患眼的临床特征及预后。
非对照病例系列。
146例患者的173只眼。
回顾性病历审查。
临床特征及预后。
所有病例均因可能患有脉络膜黑色素瘤而转诊。患者平均年龄80岁,145例(99%)为白种人,98例(67%)为女性。主要病变平均直径为10 mm,平均厚度为3 mm。病变位于颞侧103只眼(77%),累及1或2个象限123只眼(92%),位于赤道与锯齿缘之间119只眼(89%)。特征包括视网膜下出血134只眼(78%)、视网膜渗出37只眼(21%)、视网膜色素上皮(RPE)脱离48只眼(28%)以及RPE下出血45只眼(26%)。120只同侧眼(69%)和73只对侧眼(42%)发现周边RPE改变或玻璃膜疣。83只同侧眼(48%)和97只对侧眼(56%)发现黄斑RPE改变、玻璃膜疣或脉络膜新生血管。观察(平均15个月)后,80只眼(89%)病变消退或稳定,10只眼(11%)病变进展。
PEHCR是一种模拟脉络膜黑色素瘤的出血性视网膜退行性病变。