Ibrahim Shaimaa S, Awad Gehanne A S, Geneidi Ahmed, Mortada Nahed D
Ain Shams University, Department of Pharmaceutics, Cairo, Egypt.
Colloids Surf B Biointerfaces. 2009 Mar 1;69(2):225-31. doi: 10.1016/j.colsurfb.2008.11.034. Epub 2008 Dec 6.
Pluronic F68 is a nonionic, thermogelling block copolymer showing a high dehydration resistance during autoclaving due to its high cloud point (>100 degrees C). Tween 80 (with cloud point of 72.5 degrees C), is a polyoxyethylene-based cosurfactant, susceptible to temperature because of a decrease in its solubility by temperature increase. This study was done to explore whether or not, when compared with Tween 80, Pluronic F68 could be used blindly as a suitable cosurfactant for the preparation of terminally sterilized ocular submicron emulsions containing a lipid soluble drug, prednisolone acetate (PA). Various oils of variable viscosities were also tried. The results proved that no prediction can be made based on previously known physico-chemical properties alone and that emulsion stability depends on the contribution of the various emulsion components including: oil, surfactant and cosurfactant, in addition to the drug properties.
普朗尼克F68是一种非离子型热凝胶嵌段共聚物，由于其高浊点（>100℃），在高压灭菌过程中表现出高耐脱水性能。吐温80（浊点为72.5℃）是一种基于聚氧乙烯的辅助表面活性剂，由于温度升高其溶解度降低，所以对温度敏感。本研究旨在探讨与吐温80相比，普朗尼克F68是否可以盲目地用作制备含有脂溶性药物醋酸泼尼松龙（PA）的终端灭菌眼用亚微米乳剂的合适辅助表面活性剂。还尝试了各种不同粘度的油。结果证明，不能仅基于先前已知的物理化学性质进行预测，并且乳剂稳定性取决于各种乳剂成分的贡献，包括：油、表面活性剂和辅助表面活性剂，此外还取决于药物性质。
