Kirmukov A G, Aĭzikov M I, Rasulova S A, Sidiakin G P, Sham'ianov I D, Malikov V M
Farmakol Toksikol. 1991 May-Jun;54(3):35-7.
A sesquiterpenic lactone leucomyzin possessing the anti-inflammatory activity significantly reduces the extensiveness of atherosclerotic lesions of the aortas of the rabbits receiving dietary cholesterol. The drug prevents an increase of permeability of the aorta and microvessels under the influence of cholesterol, bradykinin, ovalbumin and histamine. In addition to the angioprotective action, leucomyzin possesses the hypolipidemic activity in rats with experimental hyperlipidemias and (after prolonged administration) in rabbits with cholesterol atherosclerosis. By its antiatherosclerotic and angioprotective activity leucomyzin is superior to prodectine, by its hypolipidemic action it is comparable with miscleron.
一种具有抗炎活性的倍半萜内酯——白细胞介素，能显著减少摄入膳食胆固醇的家兔主动脉粥样硬化病变的范围。该药物可防止在胆固醇、缓激肽、卵清蛋白和组胺的影响下主动脉和微血管通透性的增加。除血管保护作用外，白细胞介素对实验性高脂血症大鼠和（长期给药后）胆固醇性动脉粥样硬化家兔具有降血脂活性。就其抗动脉粥样硬化和血管保护活性而言，白细胞介素优于普罗地嗪，就其降血脂作用而言，它与米司克隆相当。
