Nelaj E, Gjata M, Lilaj I, Burazeri G, Sadiku E, Collaku L, Bare O, Tase M
Department of Internal Medicine, UHC Mother Teresa Tirane, Albania.
Hippokratia. 2008;12(4):221-4.
Microalbuminuria was originally established as a predictor of renal failure and an independent risk factor for cardiovascular disease in patients with diabetes mellitus as well as in general population. The aim of our study is to assess the relationship between microalbuminuria and the other risk factors in diabetics and their prevalence.
Sixty five patients, 22 men and 43 women with mean age 58.6+/-10.09, with type 2 diabetes, were hospitalized in the Department of Internal Medicine in the University Hospital Center "Mother Teresa" in Tirana, Albania, between March 2007 and February 2008. These patients with a mean duration of diabetes 6.09+/-5.41 were divided in two groups: with (Group A: 24 patients) and without (Group B: 41 patients) microalbuminuria and each group was evaluated for left ventricular mass index (LVMI), body mass index (BMI), glycosylated hemoglobin (HbA1C), lipid profile and intima media thickness (IMT).
The prevalence of microalbuminuria in our study was 32.3%. The prevalence of microalbuminuria in males was 37.5 and in females 62.5%. The microalbuminuric patients were older ( 59.71+/-9.87 vs 57.07+/-10.32) and had a longer duration of diabetes (7.74+/-5.74 vs 4.45+/-5.08) compared with normoalbuminuric patients (p=0.01). The Group A had significantly higher LVMI compared with Group B ( p=0.02). The prevalence of obesity (BMI>30 kg/m2) in our sample was 44.6%. In Group A the mean BMI (30.13+/-4.98) was significantly higher compared with Group B (28.00+/-3.72, p=0.04). Diabetic retinopathy was more frequent in Group A compared with Group B ( 33.3% vs 14.6%, p=0.05). The mean value of IMT was higher in Group A compared with Group B (1.28+/-0.35 vs 1.09+/-0.28, p=0.03).
In patients with type 2 diabetes and microalbuminuria LVMI, IMT, BMI, duration of diabetes was significantly higher compared with patients with type 2 diabetes and normoalbuminuria.
微量白蛋白尿最初被确立为糖尿病患者以及普通人群中肾衰竭的预测指标和心血管疾病的独立危险因素。我们研究的目的是评估糖尿病患者中微量白蛋白尿与其他危险因素之间的关系及其患病率。
2007年3月至2008年2月期间，阿尔巴尼亚地拉那“特蕾莎修女”大学医院中心内科收治了65例2型糖尿病患者，其中男性22例，女性43例，平均年龄58.6±10.09岁。这些糖尿病平均病程为6.09±5.41年的患者被分为两组：有微量白蛋白尿组（A组：24例患者）和无微量白蛋白尿组（B组：41例患者），并对每组患者的左心室质量指数（LVMI）、体重指数（BMI）、糖化血红蛋白（HbA1C）、血脂谱和内膜中层厚度（IMT）进行评估。
我们研究中微量白蛋白尿的患病率为32.3%。男性微量白蛋白尿的患病率为37.5%，女性为62.5%。与正常白蛋白尿患者相比，微量白蛋白尿患者年龄更大（59.71±9.87岁对57.07±10.32岁）且糖尿病病程更长（7.74±5.74年对4.45±5.08年）（p=0.01）。A组的LVMI显著高于B组（p=0.02）。我们样本中肥胖（BMI>30kg/m²）的患病率为44.6%。A组的平均BMI（30.13±4.98）显著高于B组（28.00±3.72，p=0.04）。A组糖尿病视网膜病变的发生率高于B组（33.3%对14.6%，p=0.05）。A组的IMT平均值高于B组（1.28±0.35对1.09±0.28，p=0.03）。
与2型糖尿病且尿白蛋白正常的患者相比，2型糖尿病且有微量白蛋白尿的患者LVMI、IMT、BMI、糖尿病病程显著更高。
