Biswas S, Saxena Q B, Upender M
Malaria Research Centre, Delhi, India.
Indian J Malariol. 1991 Mar;28(1):1-8.
The effects of Cyclosporin-A (CsA) on the growth of Plasmodia were investigated in an experimental murine model in vivo and on human malaria in vitro. Mice were inoculated with Plasmodium berghei and then treated with different doses of CsA at the patent period. The development and course of this normally lethal parasitaemia in mice was affected by treatment with CsA which is a known immunosuppressant. The drug showed complete protection at a dose of 20 mg/kg wt/day without any recrudescence. Antibody level was at the detection limit after first bout of drug-cured infection. CsA was found to be an inhibitor of P. falciparum growth in a dose dependent fashion, as the concentrations of drug in culture medium increased, a significant reduction in parasitaemia was observed.
在体内实验性小鼠模型和体外人体疟疾模型中研究了环孢素A（CsA）对疟原虫生长的影响。给小鼠接种伯氏疟原虫，然后在发病期用不同剂量的CsA进行治疗。CsA作为一种已知的免疫抑制剂，其治疗影响了小鼠体内这种通常致命的寄生虫血症的发展和病程。该药物在剂量为20mg/kg体重/天时显示出完全保护作用，且无任何复发。首次药物治愈感染后抗体水平处于检测极限。发现CsA以剂量依赖性方式抑制恶性疟原虫的生长，随着培养基中药物浓度的增加，观察到寄生虫血症显著降低。
