Kumaratilake L M, Robinson B S, Ferrante A, Poulos A
Department of Immunology, Adelaide Children's Hospital, Australia.
J Clin Invest. 1992 Mar;89(3):961-7. doi: 10.1172/JCI115678.
The polyunsaturated fatty acids docosahexaenoic acid (C22:6,n-3), eicosapentaenoic acid, arachidonic acid, and linoleic acid caused marked in vitro growth inhibition of Plasmodium falciparum, assessed by a radiometric assay. In contrast, negligible parasite killing was seen with oleic acid or docosanoic acid. Parasite killing was significantly increased when oxidized forms of polyunsaturated fatty acids were used. Antioxidants greatly reduced the fatty acid-induced killing. Mice infected with P. berghei and treated for 4 d with C22:6,n-3 showed marked reduction in parasitemia. The anemia associated with the infection was also alleviated by treatment with C22:6,n-3. The data provide new information that could be explored in order to develop new strategies in malaria treatment.
通过放射性测定法评估，多不饱和脂肪酸二十二碳六烯酸（C22:6，n-3）、二十碳五烯酸、花生四烯酸和亚油酸在体外对恶性疟原虫有显著的生长抑制作用。相比之下，油酸或二十二烷酸对疟原虫的杀伤作用可忽略不计。当使用多不饱和脂肪酸的氧化形式时，疟原虫杀伤作用显著增强。抗氧化剂大大降低了脂肪酸诱导的杀伤作用。感染伯氏疟原虫并用C22:6，n-3治疗4天的小鼠，其疟原虫血症显著降低。与感染相关的贫血也通过C22:6，n-3治疗得到缓解。这些数据提供了新的信息，可用于探索开发疟疾治疗新策略。
