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儿童复发性腹痛(RAP)和肠易激综合征(IBS)的饮食干预措施。

Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood.

作者信息

Huertas-Ceballos Angela A, Logan Stuart, Bennett Cathy, Macarthur Colin

机构信息

Neonatal Unit, EGA Hospital, UCLH, Huntley Street, London, UK, WC1E 6DH.

出版信息

Cochrane Database Syst Rev. 2009 Jan 21(1):CD003019. doi: 10.1002/14651858.CD003019.pub3.

Abstract

BACKGROUND

Between 4% and 25% of school-age children complain of recurrent abdominal pain (RAP) of sufficient severity to interfere with daily activities. It is unclear whether the diagnosis includes children with different aetiologies for their pain. For the majority no organic cause for their pain can be found on physical examination or investigation. Although most children are likely managed by reassurance and simple measures, a large range of interventions have been recommended.

OBJECTIVES

To determine the effectiveness of dietary interventions for recurrent abdominal pain in school-age children.

SEARCH STRATEGY

The Cochrane Library (CENTRAL) 2006 (Issue 4), MEDLINE (1966 to Dec 2006), EMBASE (1980 to Dec 2006), CINAHL (1982 to Dec 2007), ERIC (1966 to Dec 2006), PsycINFO (1872 to Dec 2006), LILACS (1982 to Dec 2006), SIGLE (1980 to March 2005), and JICST (1985 to 06/2000) were searched . Where appropriate, search filters were employed. Researchers working in this area were asked to identify relevant studies.

SELECTION CRITERIA

Randomised or quasi-randomised studies of any dietary treatment versus placebo or no treatment in school-age children with a diagnosis of RAP or functional gastrointestinal disorder based on the Rome II criteria.

DATA COLLECTION AND ANALYSIS

Two authors independently assessed trials for inclusion, assessed quality and extracted data. Where appropriate studies were pooled using a random effects meta-analysis.

MAIN RESULTS

Seven trials were included in this review. Two trials, including 83 participants, compared fibre supplements with placebo (Christensen 1982, Feldman 1985), with data from one study reported in two papers (Christensen 1982, Christensen 1986). The pooled odds ratio for improvement in the frequency of abdominal pain was 1.26 (0.25, 6.29). Two trials, including 90 participants (Lebenthal 1981, Dearlove 1983) compared lactose-containing with lactose-free diets. Neither reported data in a form which could be used in the meta-analysis and the former trial had a loss to follow-up of 45%. We were not able to obtain further data for either trial. Three trials (Bausserman 2005, Gavronska 2007, Young 1997) comparing supplementation with Lactobacillus with placebo met the inclusion criteria but only two (Bausserman 2005, Gavronska 2007), including a total of 168 children, provided analysable data. The pooled odds ratio for improvement of symptoms was 1.17 (95% CI 0.62, 2.21).

AUTHORS' CONCLUSIONS: There is a lack of high quality evidence on the effectiveness of dietary interventions. This review provides no evidence that fibre supplements, lactose free diets or lactobacillus supplementation are effective in the management of children with RAP.

摘要

背景

4%至25%的学龄儿童主诉反复出现腹痛(RAP),其严重程度足以干扰日常活动。目前尚不清楚该诊断是否涵盖了因不同病因导致腹痛的儿童。对于大多数儿童而言,体格检查或检查未发现疼痛的器质性原因。尽管大多数儿童可能通过安慰和简单措施进行处理,但仍推荐了大量干预措施。

目的

确定饮食干预对学龄儿童反复腹痛的有效性。

检索策略

检索了Cochrane图书馆(CENTRAL)2006年第4期、MEDLINE(1966年至2006年12月)、EMBASE(1980年至2006年12月)、CINAHL(1982年至2007年12月)、ERIC(1966年至2006年12月)、PsycINFO(1872年至2006年12月)、LILACS(1982年至2006年12月)、SIGLE(1980年至2005年3月)和JICST(1985年至2000年6月)。在适当情况下,使用了检索过滤器。该领域的研究人员被要求识别相关研究。

选择标准

基于罗马II标准,对诊断为RAP或功能性胃肠疾病的学龄儿童进行的任何饮食治疗与安慰剂或不治疗的随机或半随机研究。

数据收集与分析

两位作者独立评估试验是否纳入,评估质量并提取数据。适当情况下,使用随机效应荟萃分析对研究进行合并。

主要结果

本综述纳入了7项试验。两项试验,包括83名参与者,将纤维补充剂与安慰剂进行了比较(Christensen 1982,Feldman 1985),一项研究的数据发表在两篇论文中(Christensen 1982,Christensen 1986)。腹痛频率改善的合并优势比为1.26(0.25,6.29)。两项试验,包括90名参与者(Lebenthal 1981,Dearlove 1983),比较了含乳糖饮食与无乳糖饮食。两项试验均未以可用于荟萃分析的形式报告数据,且前一项试验有45%的失访率。我们无法为任何一项试验获取进一步的数据。三项比较补充乳酸杆菌与安慰剂的试验(Bausserman 2005,Gavronska 2007,Young 1997)符合纳入标准,但只有两项(Bausserman 2005,Gavronska 2007),共包括168名儿童,提供了可分析的数据。症状改善的合并优势比为1.17(95%CI 0.62,2.21)。

作者结论

缺乏关于饮食干预有效性的高质量证据。本综述未提供证据表明纤维补充剂、无乳糖饮食或补充乳酸杆菌对RAP儿童的治疗有效。

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