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心脏不停跳技术下的多瓣膜手术

Multiple valve surgery with beating heart technique.

作者信息

Ricci Marco, Macedo Francisco Igor B, Suarez Maria R, Brown Michael, Alba Julia, Salerno Tomas A

机构信息

Division of Cardiothoracic Surgery, University of Miami, Miller School of Medicine, and Jackson Memorial Hospital, Miami, Florida, USA.

出版信息

Ann Thorac Surg. 2009 Feb;87(2):527-31. doi: 10.1016/j.athoracsur.2008.10.030.

Abstract

BACKGROUND

Multiple valve surgery was performed utilizing beating heart technique through simultaneous antegrade/retrograde perfusion with blood. We herein report our experience with this technique in patients with multiple valve disease processes.

METHODS

Of 520 consecutive patients operated upon utilizing this method between 2000 and 2007, 59 patients underwent multiple valve surgery. Mean age was 54.2 +/- 13.8 years (range, 21 to 83) with 41 males (69.5%) and 18 females (30.5%). Double-valve and triple-valve operations were performed in 54 and 5 patients, respectively.

RESULTS

Of 32 mitral valve replacements, there were 30 biological (93.8%) and 2 mechanical (6.2%) mitral valves. Aortic valve replacement was performed in 25 patients: 22 (88%) with biological and 3 (12%) with mechanical prostheses. Two patients had mitral and tricuspid valve repair. The most common procedure was mitral valve replacement plus tricuspid valve repair (16 patients; 27.1%), mitral valve replacement plus aortic replacement (14 patients; 23.7%), and mitral valve repair plus tricuspid repair (13 patients; 22%). Concomitant coronary artery bypass grafting was performed in 7 (11.8%) of 59 patients. Mean hospital stay was 25.6 +/- 29.6 days (range, 3 to 195; median, 17). Early mortality (less than 30 days) occurred in 5 patients (8.4%), and late mortality (more than 30 days) occurred in 2 patients (3.4%). Reoperation for bleeding was needed in 5 patients (8.4%). Intra-aortic balloon pump was required preoperatively and postoperatively in 4 and 1 patients, respectively. Clinical and echocardiographic follow-up in 33 patients at 11.8 +/- 16.4 months (range, 1 to 80) showed preserved postoperative left ventricular ejection fraction. Three patients had perivalvular leaks on follow-up but required no surgery. Nineteen patients were lost to follow-up.

CONCLUSIONS

This study demonstrates the feasibility and safety of beating heart techniques in multiple valve operations. Further studies are needed to fully evaluate the potential benefits of this method of myocardial perfusion as a means to eliminate ischemia-reperfusion injury, and to preserve ventricular function in multiple valvular surgery.

摘要

背景

采用心脏跳动技术,通过顺行/逆行同步血液灌注进行多瓣膜手术。我们在此报告我们在患有多种瓣膜疾病的患者中应用该技术的经验。

方法

在2000年至2007年期间,连续520例采用该方法进行手术的患者中,59例接受了多瓣膜手术。平均年龄为54.2±13.8岁(范围21至83岁),其中男性41例(69.5%),女性18例(30.5%)。分别有54例和5例患者进行了双瓣膜和三瓣膜手术。

结果

在32例二尖瓣置换术中,有30例(93.8%)使用生物瓣膜,2例(6.2%)使用机械瓣膜。25例患者进行了主动脉瓣置换:22例(88%)使用生物瓣膜,3例(12%)使用机械瓣膜。2例患者进行了二尖瓣和三尖瓣修复。最常见的手术是二尖瓣置换加三尖瓣修复(16例患者;27.1%)、二尖瓣置换加主动脉瓣置换(14例患者;23.7%)以及二尖瓣修复加三尖瓣修复(13例患者;22%)。59例患者中有7例(11.8%)同时进行了冠状动脉旁路移植术。平均住院时间为25.6±29.6天(范围3至195天;中位数17天)。5例患者(8.4%)发生早期死亡(30天内),2例患者(3.4%)发生晚期死亡(30天后)。5例患者(8.4%)因出血需要再次手术。分别有4例和1例患者在术前和术后需要主动脉内球囊泵。33例患者在11.8±16.4个月(范围1至80个月)进行的临床和超声心动图随访显示术后左心室射血分数得以保留。3例患者在随访时出现瓣周漏,但无需手术。19例患者失访。

结论

本研究证明了心脏跳动技术在多瓣膜手术中的可行性和安全性。需要进一步研究以充分评估这种心肌灌注方法作为消除缺血再灌注损伤以及在多瓣膜手术中保留心室功能手段的潜在益处。

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