Gersak B
Department of Cardiovascular Surgery, University Medical Center, Ljubljana, Slovenia.
Heart Surg Forum. 2000;3(3):232-7.
Beating heart (off-pump) coronary artery bypass grafting (CABG) techniques have led us to consider the possibility of performing mitral valve repairs and replacements (with or without CABG) on the beating heart.
If CABG had to be performed in addition to the valve procedure, CABG was done first on the beating heart without cardiopulmonary bypass, if possible. For the valve procedure, the aorta was cross-clamped and the beating-heart status was maintained throughout the whole procedure with continuous, warm, oxygenated blood coronary-sinus perfusion.
We used this technique in 23 patients with extremely low ejection fractions, 78% of whom were in New York Heart Association (NYHA) class 4 and 17% of whom were in New York Heart Association (NYHA) class 3. The procedures were: mitral-tricuspid (11 patients), mitral-aortic (7 patients), mitral-tricuspid CABG (1 patient), and mitral-aortic CABG (4 patients). The total early mortality was 13% (3 of 23 patients). Two were in-hospital deaths. One patient with triple-vessel disease and acute mitral insufficiency (AMI) on intra aortic balloon pump had been operated on six days after AMI. The cause of death was systemic meticillin resistant staphylococcus aureus infection. (Eight days prior to our operation, arthrodesis of the talocrural joint was performed by an orthopedic surgeon.) The other death was a female patient who was operated on after previous multiple cerebrovascular infarctions (CVIs) (cause of the death was CVI). In addition, one patient died one month after the operation because of prosthetic valve endocarditis on aortic and mitral valves (silver-coated silzone aortic and mitral valves were implanted because of chronic latent asymptomatic tibial osteitis). None of these deaths were cardiac related.
The main advantages of beating heart surgery are: 1) the perfused myocardial muscle, 2) the heart not doing any work, 3) no reperfusion injury, 4) the possibility for ablation of atrial fibrillation on the beating heart, and 5) testing of the mitral valve repair is done in real physiologic conditions in the state of left ventricle beating tonus. The procedure could be the procedure of choice for the valve operation or combined operations in high-risk patients with low ejection fractions.
不停跳冠状动脉搭桥术(CABG)技术促使我们考虑在心脏跳动的情况下进行二尖瓣修复和置换手术(无论是否同时进行CABG)的可能性。
如果除瓣膜手术外还必须进行CABG,若有可能,首先在心脏跳动且不使用体外循环的情况下进行CABG。对于瓣膜手术,夹闭主动脉,并在整个手术过程中通过持续、温热、含氧血液经冠状窦灌注来维持心脏跳动状态。
我们将此技术应用于23例射血分数极低的患者,其中78%为纽约心脏协会(NYHA)心功能4级,17%为NYHA心功能3级。手术类型包括:二尖瓣 - 三尖瓣手术(11例患者)、二尖瓣 - 主动脉手术(7例患者)、二尖瓣 - 三尖瓣CABG(1例患者)以及二尖瓣 - 主动脉CABG(4例患者)。早期总死亡率为13%(23例患者中有3例)。2例为住院死亡。1例患有三支血管病变且在主动脉内球囊反搏支持下的急性二尖瓣关闭不全(AMI)患者,在AMI发生6天后接受手术。死亡原因是耐甲氧西林金黄色葡萄球菌全身感染。(在我们手术前8天,一名骨科医生对其踝关节进行了关节融合术。)另1例死亡患者为女性,在既往多次脑血管梗死(CVI)后接受手术(死亡原因是CVI)。此外,1例患者在术后1个月因人工瓣膜心内膜炎死亡,累及主动脉瓣和二尖瓣(因慢性潜在无症状胫骨骨炎植入了镀银Silzone主动脉瓣和二尖瓣)。这些死亡均与心脏无关。
不停跳心脏手术的主要优点包括:1)心肌持续灌注;2)心脏不做功;3)无再灌注损伤;4)有可能在跳动的心脏上消融房颤;5)在左心室跳动张力状态下的真实生理条件下对二尖瓣修复进行测试。对于射血分数低的高危患者,该手术可能是瓣膜手术或联合手术的首选术式。