铅及其他抑制剂对甘氨酸激活钾依赖性对硝基苯磷酸酶活性的影响。
Effects of lead and other inhibitors on the activation of K+-dependent p-nitrophenylphosphatase activity by glycine.
作者信息
Suketa Y, Kawamoto J
出版信息
J Toxicol Environ Health. 1977 Jan;2(3):663-9. doi: 10.1080/15287397709529468.
The in vitro and in vivo effects of lead on the activation of K+-dependent p-nitrophenylphosphatase activity by glycine were investigated in plasma membranes of male Wistar rat livers. This activation was markedly inhibited by lead in vitro (0.1-5.0 mM) and in vivo (intraperitoneal injection of lead at 4, 8, or 20 mg per 100 g body weight). On the other hand, the in vitro activation of this K+-dependent activity by glycine was about 77% inhibited by ouabain (10 micronM), but about 100% inhibited by oligomycin (20 micronM).
研究了铅对甘氨酸激活雄性Wistar大鼠肝脏质膜中钾离子依赖性对硝基苯磷酸酶活性的体外和体内影响。在体外（0.1 - 5.0 mM）和体内（腹腔注射每100克体重4、8或20毫克铅），这种激活作用均被铅显著抑制。另一方面，哇巴因（10微摩尔）对甘氨酸体外激活这种钾离子依赖性活性的抑制作用约为77%，而寡霉素（20微摩尔）的抑制作用约为100%。
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