用于神经信号记录的基于压电电机的微驱动器。

Piezo motor based microdrive for neural signal recording.

作者信息

Yang Sungwook, Lee Semin, Park Kitae, Jeon Hyojin, Huh Yeowool, Cho Jeiwon, Shin Hee-Sup, Yoon Eui-sung

机构信息

Nano-Bio Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, Korea.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2008;2008:3364-7. doi: 10.1109/IEMBS.2008.4649927.

DOI:10.1109/IEMBS.2008.4649927

PMID:19163430

Abstract

The miniature piezo motor based microdrive which is applicable to the neural signal recording in mice is presented. The microdrive is manipulated by the micromotion of the mobile coupled to the piezo motor generating the flexural vibration within the range of 3.8 mm, with the resolution of 60nm. Advancement of electrodes in a mouse brain is monitored by an integrated MR (Magneto-Resistive) sensor. This microdrive has the length of 6.5mm, the width of 6.5 mm, the height of 12 mm and the total weight of 1.63 g only, including PCB for neural signal recording. The displacement of the microelectrode was evaluated and verified as applying the inputs with 5 to 100 pulses, 30 times to the piezo motor according to various driving voltages. The neural signals from the single thalamic neurons in an awake and freely moving mouse were recorded successfully with the presented microdrive.

摘要

本文介绍了一种适用于小鼠神经信号记录的基于微型压电电机的微驱动器。该微驱动器通过与压电电机相连的移动部件的微运动进行操作，压电电机产生3.8毫米范围内的弯曲振动，分辨率为60纳米。通过集成的磁阻（MR）传感器监测电极在小鼠大脑中的推进情况。该微驱动器长度为6.5毫米，宽度为6.5毫米，高度为12毫米，总重量仅为1.63克，包括用于神经信号记录的印刷电路板。根据不同的驱动电压，对压电电机施加5至100个脉冲的输入，共30次，对微电极的位移进行了评估和验证。使用所介绍的微驱动器成功记录了清醒自由活动小鼠单个丘脑神经元的神经信号。