Bonuccelli U, Nuti A, Monzani F, De Negri F, Muratorio A
Instituto di Clinica Neurologica, Università di Pisa, Italy.
Funct Neurol. 1991 Apr-Jun;6(2):171-5.
Several cases of association between cerebellar ataxia and hypothyroidism have been reported, in which cerebellar symptoms regressed after euthyroid state was obtained, suggesting an etiologic relationship between hypothyroidism and ataxia. We present a further case of hypothyroidism and ataxia, with a peculiar positive family history for both thyroid and cerebellar disorders. Long-term replacement therapy with L-thyroxine determined the regression of hypothyroidism; however, no improvement in cerebellar symptoms was observed. The lack of response of the neurologic symptoms to L-thyroxine treatment suggests the absence of an etiological relationship between thyroid disease and cerebellar disease in this case.
已有多例小脑共济失调与甲状腺功能减退相关的报道，其中小脑症状在甲状腺功能正常状态恢复后消退，提示甲状腺功能减退与共济失调之间存在病因学关系。我们报告了另一例甲状腺功能减退和共济失调的病例，该病例在甲状腺疾病和小脑疾病方面均有特殊的阳性家族史。长期使用左甲状腺素替代治疗使甲状腺功能减退得到缓解；然而，未观察到小脑症状有所改善。神经症状对左甲状腺素治疗无反应表明，该病例中甲状腺疾病与小脑疾病之间不存在病因学关系。
