Sekhavat Leila, Tabatabaii Afsar, Dalili Maryam, Farajkhoda Tahminah, Tafti Atefah Dehghani
Department of Obstetrics and Gynecology, Shahid Sedughi Hospital, Shahid Sedughi University of Medical Sciences and Health Services, Yazd, Iran.
J Matern Fetal Neonatal Med. 2009 Jan;22(1):72-5. doi: 10.1080/14767050802353580.
To assess the efficacy and safety of tranexamic acid in reducing blood loss at caesarian section (CS).
A prospective randomised study conducted on 90 primiparas divided into two groups who underwent CS. The study group, 45 women, received tranexamic acid immediately before CS, whereas the control group, 45 women received placebo. Blood loss volume was measured from the end of CS to 2 h postpartum and compared between the two groups. Hemoglobin (Hb) and hematocrit (Hct) were tested 24 h after CS and compared between the two groups.
Tranexamic acid significantly reduced the blood loss from the end of CS to 2 h postpartum; 28.02 +/- 5.53 mL in the tranexamic group versus 37.12 +/- 8.97 mL in the control group (p = 0.000). Hb 24 h after CS was significantly greater in tranexamic group than control group (12.57 +/- 1.33 in the tranexamic group and 11.74 +/- 1.14 in the control group, p = 0.002). No complications or side effects were reported in either group.
Tranexamic acid statistically reduces blood loss from end to 2 h after CS and its use was not associated with any side effects or complications. Consequently, tranexamic acid can be used safely and effectively to reduce bleeding resulting from CS.
评估氨甲环酸在剖宫产术中减少失血的有效性和安全性。
对90例初产妇进行前瞻性随机研究，将其分为两组并接受剖宫产。研究组45名女性，在剖宫产即将开始前接受氨甲环酸，而对照组45名女性接受安慰剂。测量剖宫产结束至产后2小时的失血量，并在两组间进行比较。剖宫产术后24小时检测血红蛋白（Hb）和血细胞比容（Hct），并在两组间进行比较。
氨甲环酸显著减少了剖宫产结束至产后2小时的失血量；氨甲环酸组为28.02±5.53毫升，而对照组为37.12±8.97毫升（p = 0.000）。剖宫产术后24小时，氨甲环酸组的Hb显著高于对照组（氨甲环酸组为12.57±1.33，对照组为11.74±1.14，p = 0.002）。两组均未报告并发症或副作用。
氨甲环酸在统计学上可减少剖宫产结束至术后2小时的失血量，且其使用与任何副作用或并发症无关。因此，氨甲环酸可安全有效地用于减少剖宫产引起的出血。
