水杨酸在类风湿性关节炎患儿体内的处置情况。
Salicylic acid disposition in children with rheumatoid arthritis.
作者信息
Barzaghi N, Lamedica G, Gatti G, Cottafava F, Massocco D, Marchese N
机构信息
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
出版信息
Fundam Clin Pharmacol. 1991;5(4):285-90. doi: 10.1111/j.1472-8206.1991.tb00723.x.
Abstract
The plasma level profile of SA and SUA after a single oral dose of ASA was studied in 8 children with juvenile rheumatoid arthritis, aged 3.5-15.0 years. Pharmacokinetic parameters were on average similar to those reported in the literature for adult subjects, although a somewhat larger intersubject variability was found.
摘要
在8名3.5至15.0岁的幼年类风湿性关节炎患儿中研究了单次口服阿司匹林（ASA）后水杨酸（SA）和尿酸（SUA）的血浆水平变化情况。药代动力学参数平均而言与文献中报道的成年受试者相似，尽管受试者间的变异性稍大。
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