丙型肝炎感染与否的血液透析患者对乙型肝炎病毒疫苗接种的反应
Response to hepatitis B virus vaccination in haemodialysis patients with and without hepatitis C infection.
作者信息
Sorkhi H, Roushan M R H, Al Hashemi G H, Dooki M R E, Bai S
机构信息
Department of Paediatric Nephrology, Babol Medical University, Babol, Islamic Republic of Iran.
出版信息
East Mediterr Health J. 2008 Jul-Aug;14(4):798-803.
The aim of this study was to determine the efficacy of hepatitis B virus (HBV) vaccination and the response to vaccine in individuals on haemodialysis with and without HCV infection. From April 2000 to September 2003 all haemodialysis patients referred to the haemodialysis department in a Babol hospital received 4 microg vaccine intramuscularly at 0, 1, and 6 months. All were negative for HBV infection markers (HBcAb, HBsAg and HBsAb). Of 62 patients, 53 (85.5%) responded to vaccination and 26 (49.1%) were high responders. All individuals with HCV infection responded to vaccination. Duration of haemodialysis had no effect on response to vaccination.
本研究的目的是确定乙肝病毒（HBV）疫苗接种的效果以及感染丙型肝炎病毒（HCV）与否的血液透析患者对疫苗的反应。2000年4月至2003年9月期间，所有转诊至巴博勒一家医院血液透析科的患者在第0、1和6个月时接受了4微克疫苗的肌肉注射。所有患者的乙肝感染标志物（乙肝核心抗体、乙肝表面抗原和乙肝表面抗体）均为阴性。62例患者中，53例（85.5%）对疫苗接种有反应，26例（49.1%）为高反应者。所有感染HCV的个体对疫苗接种均有反应。血液透析时间对疫苗接种反应无影响。
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