Zhang Zongqi, Tang Songwei, Zhu Liang, Wu Guoqiang, Jiang Zonglai, Shi Bin
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Dec;25(6):1322-6.
Portal hypertension is a common physiopathological change in liver cirrhosis. In this study, rabbits were used and the model of pre-hepatic portal hypertension (PHT) was induced by partial ligation of portal vein in two steps. We measured the diameters of portal vein and small mesenteric vein at different time-points. Then we detected the stress forces induced by blood flow in varicose veins and in portal vein; such forces included hydrostatic pressure, shear stress and circumferential stress. With the increase of the diameter of varicose small mesenteric vein, the hydrostatic pressure and circumferential stress gradually elevated and shear stress descended markedly in both the portal vein and the small mesenteric vein of PHT rabbits, between which there was a positive linear correlation. The findings in our study indicate that the complications of PHT are partially attributable to the environment of lower shear stress and higher circumferential stress in which the blood vessels of portal venous system live.
门静脉高压是肝硬化常见的生理病理变化。在本研究中，选用家兔，分两步通过部分结扎门静脉诱导肝前性门静脉高压（PHT）模型。我们在不同时间点测量门静脉和肠系膜小静脉的直径。然后我们检测曲张静脉和门静脉中血流诱导的应力；这些应力包括静水压力、剪切应力和周向应力。随着肠系膜小静脉曲张直径的增加，PHT家兔门静脉和肠系膜小静脉中的静水压力和周向应力逐渐升高，而剪切应力显著下降，两者之间呈正线性相关。我们的研究结果表明，PHT的并发症部分归因于门静脉系统血管所处的低剪切应力和高周向应力环境。
