Gao Jieming, Ming Jing, Gu Zhongwei, Zhang Xingdong
College of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Dec;25(6):1338-43.
9-nitro camptothecin (9-NC) loaded amphiphilic copolymer micelles were prepared with solvent evaporation method. The effects of temperature, distilled water volume, stirring rate, and drug input amount on the size and drug content of micelles were further discussed. As a result, well dispersed spherical micelles with drug content of 4.9 percent and 50 -70 nanometers in diameter were achieved with the following preparation conditions: water bath temperature 60 degrees C , distilled water amount 16 ml, stirring rate 6 500 r/min, and drug input amount 1.2 mg. 9-NC release profiles in vitro illustrated that drug release from micelles included initial burst release and following controlled release. The release rate was decreased with the increase of drug content.
采用溶剂蒸发法制备了载9-硝基喜树碱（9-NC）的两亲性共聚物胶束。进一步探讨了温度、蒸馏水体积、搅拌速率和药物投入量对胶束粒径和药物含量的影响。结果表明，在以下制备条件下可得到分散良好的球形胶束，其药物含量为4.9%，直径为50-70纳米：水浴温度60℃，蒸馏水用量16毫升，搅拌速率6500转/分钟，药物投入量1.2毫克。9-NC的体外释放曲线表明，胶束药物释放包括初始突释和随后的控释。释放速率随药物含量的增加而降低。
