Giugliano D, Lefebvre P J
Chair of Diabetology and Dietetics, First Faculty of Medicine, University of Naples, Italy.
Horm Metab Res. 1991 Jun;23(6):251-6. doi: 10.1055/s-2007-1003667.
The discovery of several endogenous substances with morphine-like activity (endorphins and enkephalins) which possess potent behavioral effects, interfering with food and water intake, has led to suggest their implications in the pathogenesis of human obesity. This suggestion is mainly based on: 1) the ability of opiate antagonists naloxone and naltrexone to reduce food intake in some particular situations associated with obesity: 2) the existence of raised plasma levels of beta-endorphin in obese children and adults not corrected by weight loss; and 3) the increased responsiveness to the metabolic and hormonal effects of opiate agonism and antagonism found in obese but not in normal weight subjects. Although the problem still awaits a definite answer, it seems not hazardous to hypothesize a role for beta-endorphin in some pathogenetic events associated with human obesity.
几种具有吗啡样活性的内源性物质（内啡肽和脑啡肽）的发现，这些物质具有强大的行为效应，会干扰食物和水的摄入，这表明它们与人类肥胖的发病机制有关。这一推测主要基于以下几点：1）阿片类拮抗剂纳洛酮和纳曲酮在某些与肥胖相关的特定情况下能够减少食物摄入；2）肥胖儿童和成年人血浆β-内啡肽水平升高，且体重减轻后并未恢复正常；3）肥胖受试者而非正常体重受试者对阿片激动剂和拮抗剂的代谢及激素效应反应增强。尽管这个问题仍有待明确答案，但推测β-内啡肽在一些与人类肥胖相关的发病过程中起作用似乎并无风险。
