Han Jong-Min, Kim Min-Jung, Baek Seung-Hwa, An Sojin, Jin Yue-Yan, Chung Hae-Gon, Baek Nam-In, Choi Myung-Sook, Lee Kyung-Tae, Jeong Tae-Sook
National Research Laboratory of Lipid Metabolism & Atherosclerosis, KRIBB, Daejeon 305-806, Korea.
J Agric Food Chem. 2009 Feb 25;57(4):1267-74. doi: 10.1021/jf802639y.
Antiatherosclerotic effects of ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal (ESJ) were investigated in low-density lipoprotein receptor deficient (LDLR(-/-)) mice. The Western diet-induced high levels of total cholesterol and triglyceride were similar in the ESJ and control groups. However, circulating oxidized LDL was significantly decreased in the ESJ group (p < 0.05). ESJ also markedly decreased aortic expression levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta), and reduced the aortic lesion formation and macrophage accumulation by 36.7% (p < 0.05) and 43% (p < 0.01) in the control group, respectively. Additionally, ESJ inhibited atherogenic properties with cytokine-induced surface expression of cell adhesion molecules, chemokines, and monocyte adhesion to the human umbilical vein endothelial cells (HUVECs), and simultaneously suppressed nuclear factor-kappaB (NF-kappaB) activation. These results suggest that ethanolic extracts of Artemisia princeps Pampanini cv. Sajabal contributes to the antiatherosclerotic and anti-inflammatory activities in LDLR(-/-) mice.
研究了南牡蒿栽培品种Sajabal（ESJ）乙醇提取物对低密度脂蛋白受体缺陷（LDLR(-/-)）小鼠的抗动脉粥样硬化作用。西式饮食诱导的总胆固醇和甘油三酯高水平在ESJ组和对照组中相似。然而，ESJ组中循环氧化型LDL显著降低（p < 0.05）。ESJ还显著降低了主动脉中细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）、肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）的表达水平，并使对照组的主动脉病变形成和巨噬细胞积累分别减少了36.7%（p < 0.05）和43%（p < 0.01）。此外，ESJ通过细胞因子诱导的细胞黏附分子、趋化因子的表面表达以及单核细胞对人脐静脉内皮细胞（HUVECs）的黏附抑制了动脉粥样硬化特性，同时抑制了核因子-κB（NF-κB）的激活。这些结果表明，南牡蒿栽培品种Sajabal的乙醇提取物有助于在LDLR(-/-)小鼠中发挥抗动脉粥样硬化和抗炎活性。
