Ju Shenghong, McLennan Gordon, Bennett Stacy L, Liang Yun, Bonnac Laurent, Pankiewicz Krzysztof W, Jayaram Hiremagalur N
Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
J Vasc Interv Radiol. 2009 Mar;20(3):410-4. doi: 10.1016/j.jvir.2008.12.408. Epub 2009 Jan 23.
The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.
本研究旨在评估大鼠经股动脉肝动脉插管的技术可行性，并描述可用于大鼠肿瘤的成像技术。将总共106个N1-S1细胞接种到74只大鼠的左叶。对17只大鼠尝试进行经股动脉血管造影。40只动物在血管造影前2周用磁共振成像测量肿瘤体积。63只动物的肿瘤生长。血管造影在16只大鼠中成功。1周和2周后平均肿瘤体积分别为0.13 mL和0.9 mL。总之，在该动物模型中经股动脉肝动脉插管是可行的。
