Illarramendi Mañas J J, Salgado E, Lainez N, Arrazubi V, Teijeira L, Vera R
Servicio de Oncología Médica, Hospital de Navarra, Pamplona 31008, Spain.
An Sist Sanit Navar. 2008;31 Suppl 3:135-45.
Orbital metastases are a defined subgroup within ocular affection secondary to the distant spread of breast cancer. We review the published experience on the incidence of orbit extension from this type of tumour, with reference made to our experience as medical oncologists, together with the most common clinical features and the relevant aspects for imaging and histopathological diagnoses. The therapy for orbital metastases from breast cancer is included within the systemic therapy required by the distant spread of the disease, with some clinical benefits obtained from hormone therapy, chemotherapy and monoclonal antibodies. Palliative radiation and surgery may also play an important role in providing care to these patients. Although there are some published cases with long-term survival, the prognosis for these patients is poor, and new advances in knowledge and therapy are needed for this complication due to breast cancer.
眼眶转移瘤是继发于乳腺癌远处转移的眼部病变中的一个特定亚组。我们回顾了已发表的关于此类肿瘤眼眶转移发生率的经验,并参考了我们作为肿瘤内科医生的经验,以及最常见的临床特征和影像学及组织病理学诊断的相关方面。乳腺癌眼眶转移的治疗包含在疾病远处转移所需的全身治疗中,激素治疗、化疗和单克隆抗体可带来一些临床益处。姑息性放疗和手术在为这些患者提供治疗方面也可能发挥重要作用。尽管有一些已发表的长期生存病例,但这些患者的预后较差,对于这种乳腺癌并发症,需要在知识和治疗方面取得新进展。