Piccoli Jacqueline C Escobar, Gottlieb Maria Gabriela Valle, Castro Luciano, Bodanese Luiz Carlos, Manenti Euler Roberto Fernandes, Bogo Mauricio Reis, Peres Alessandra, Rocha Maria Izabel U M da, Cruz Ivana Beatrice Mânica da
Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, RS, Brasil.
Arq Bras Endocrinol Metabol. 2008 Nov;52(8):1367-73. doi: 10.1590/s0004-27302008000800027.
Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
代谢综合征（MS）是一组心血管危险因素，如高血压、血脂异常、肥胖和II型糖尿病。在此，我们进行了一项病例对照研究，分析了616名受试者中894G>T内皮型一氧化氮合酶基因多态性（NOS3）与MS之间的关联。基因型频率为TT = 9.3%，GG = 37.2%，TG = 53.6%，等位基因频率为T = 0.36，G = 0.64。我们观察到男性MS组的TT基因型频率高于对照组（p = 0.02），且不受其他变量影响。我们发现女性中高血压与TT基因型之间存在关联。我们的数据表明，尽管可能存在性别差异，但894G>T在高血压等代谢风险与MS之间的机制相互作用中起重要作用。
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