一氧化氮合酶 3 基因多态性及其与亚洲印第安人深静脉血栓形成的关系。
The nitric oxide synthase 3 gene polymorphisms and their association with deep vein thrombosis in Asian Indian patients.
机构信息
All India Institute of Medical Sciences, New Delhi, India.
出版信息
Clin Chim Acta. 2010 May 2;411(9-10):649-52. doi: 10.1016/j.cca.2010.01.025. Epub 2010 Jan 28.
BACKGROUND
Endothelium derived nitric oxide is formed from l-arginine by endothelial nitric oxide synthase encoded by the nitric oxide synthase 3 (NOS3) gene. Nitric oxide possesses a variety of protective effects on endothelial cells and therefore NOS3 is a logical candidate gene to be investigated for the susceptibility of deep vein thrombosis (DVT).
METHODS
One hundred consecutive patients (M: F=56:44) with idiopathic deep vein thrombosis and an equal number of age and sex matched healthy controls were the study subjects. All study subjects were typed for five NOS3 polymorphisms (-786C/T, -922A/G, 894G/T, Intron 4 VNTR, and Intron 23 G10T).
RESULTS
Two polymorphisms (-922A/G and 894G/T) are showing their association with DVT. -922A/G shows both genotypic (P=0.0218; chi2=5.25; O.R=1.94) as well as allelic association (P=0.0014; chi2=10.19; O.R=2.0) while 894G/T shows only allelic (P=0.04; chi2=3.93; O.R=3.93) association with DVT.
CONCLUSION
Susceptibility to DVT in North Indian Asian patients may be associated with some variants of NOS3 gene.
背景
内皮细胞衍生的一氧化氮由内皮型一氧化氮合酶（NOS3）基因编码的 l-精氨酸形成。一氧化氮对内皮细胞具有多种保护作用，因此 NOS3 是研究深静脉血栓形成（DVT）易感性的逻辑候选基因。
方法
100 例特发性深静脉血栓形成患者（M：F=56:44）和相同数量的年龄和性别匹配的健康对照者为研究对象。所有研究对象均进行 5 种 NOS3 多态性（-786C/T、-922A/G、894G/T、内含子 4 VNTR 和内含子 23 G10T）的分型。
结果
两种多态性（-922A/G 和 894G/T）与 DVT 相关。-922A/G 显示基因型（P=0.0218；chi2=5.25；O.R=1.94）和等位基因关联（P=0.0014；chi2=10.19；O.R=2.0），而 894G/T 仅显示等位基因关联（P=0.04；chi2=3.93；O.R=3.93）与 DVT 相关。
结论
北印度亚洲患者 DVT 的易感性可能与 NOS3 基因的某些变体有关。
Zotero 插件