荜茇果实中的降血脂化合物
Antihyperlipidemic compounds from the fruit of Piper longum L.
作者信息
Jin Zhuang, Borjihan Gereltu, Zhao Ruiguo, Sun Zhaorigetu, Hammond Gerald B, Uryu Toshiyuki
机构信息
Institute of Macromolecular Chemistry and Mongolian Medicine, Inner Mongolia University, Huhhot 010021, China.
出版信息
Phytother Res. 2009 Aug;23(8):1194-6. doi: 10.1002/ptr.2630.
DOI:10.1002/ptr.2630
PMID:19172581
Abstract
A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.
摘要
对荜茇果实乙醇提取物进行生物测定导向分离，得到了荜茇明宁碱、胡椒碱和胡椒壬碱，它们是主要的降血脂成分。它们在体内表现出显著的降血脂活性，与市售降血脂药物辛伐他汀相当。
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