Pellecchia Maurizio, Bertini Ivano, Cowburn David, Dalvit Claudio, Giralt Ernest, Jahnke Wolfgang, James Thomas L, Homans Steve W, Kessler Horst, Luchinat Claudio, Meyer Bernd, Oschkinat Hartmut, Peng Jeff, Schwalbe Harald, Siegal Gregg
Burnham Institute for Medical Research, La Jolla, California 92037, USA.
Nat Rev Drug Discov. 2008 Sep;7(9):738-45. doi: 10.1038/nrd2606.
In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.
在过去十年中,学术界和工业界越来越认识到利用核磁共振(NMR)光谱监测分子间相互作用的能力作为药物发现工具的潜力。在这篇观点文章中,我们重点介绍了NMR在药物发现中的一些主要应用,聚焦于活性分子和先导化合物的产生,并对其当前和潜在效用进行了批判性分析。