Orange Jordan S
University of Pennsylvania School of Medicine, Joseph Stokes Jr Research Institute of The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, ARC 1016H, Philadelphia, Pennsylvania 19104, USA.
Nat Rev Immunol. 2008 Sep;8(9):713-25. doi: 10.1038/nri2381.
The natural killer (NK)-cell immunological synapse is the dynamic interface formed between an NK cell and its target cell. Formation of the NK-cell immunological synapse involves several distinct stages, from the initiation of contact with a target cell to the directed delivery of lytic-granule contents for target-cell lysis. Progression through the individual stages is regulated, and this tight regulation underlies the precision with which NK cells select and kill susceptible target cells (including virally infected cells and cancerous cells) that they encounter during their routine surveillance of the body.
自然杀伤(NK)细胞免疫突触是NK细胞与其靶细胞之间形成的动态界面。NK细胞免疫突触的形成涉及几个不同阶段,从与靶细胞接触的起始到为裂解靶细胞而定向递送溶细胞颗粒内容物。各个阶段的进展受到调控,这种严格调控是NK细胞在对身体进行常规监测期间精准选择并杀死所遇到的易感靶细胞(包括病毒感染细胞和癌细胞)的基础。