Luis-Hidalgo Mar, Piñana José Luis, Solano Carlos, Planelles Dolores
Centro de Transfusión de la Comunidad Valenciana, 46014 Valencia, Spain.
Hospital Clínico Universitario de Valencia, 46010 Valencia, Spain.
Cells. 2025 Jul 16;14(14):1091. doi: 10.3390/cells14141091.
This paper conducts a literature review on the role of natural killer cells in haploidentical hematopoietic stem cell transplantation. Theoretical concepts related to genes are introduced regarding their structure, nomenclature, genetic organization, polymorphism, and inheritance pattern, types of KIR proteins and receptors, HLA ligands for KIR receptors, and the definition of different NK alloreactivity prediction models for the donor of haploidentical hematopoietic stem cell transplantation and the recipient. These models include the following and consider incompatibility: ligand-ligand, receptor-ligand, gene-gene, and KIR haplotype models or the donor group. These models consider the presence or absence of specific ligands or receptors and/or genes in the donor and recipient to predict alloreactivity. Determining the best model for predicting KIR alloreactivity and its significance in donor selection algorithms for haploidentical transplantation is still under investigation.
本文对自然杀伤细胞在单倍体造血干细胞移植中的作用进行了文献综述。介绍了与基因相关的理论概念，包括其结构、命名、遗传组织、多态性和遗传模式、KIR蛋白和受体的类型、KIR受体的HLA配体，以及单倍体造血干细胞移植供体和受体不同NK同种异体反应性预测模型的定义。这些模型包括以下几种，并考虑不相容性：配体-配体、受体-配体、基因-基因和KIR单倍型模型或供体组。这些模型考虑供体和受体中特定配体或受体和/或基因的存在与否来预测同种异体反应性。确定预测KIR同种异体反应性的最佳模型及其在单倍体移植供体选择算法中的意义仍在研究中。
