Lagrada Leizel P, Uehara Naruo, Kawahara Kazuo
Department of Health Policy Science, Graduate School of Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519 Japan.
Kekkaku. 2008 Dec;83(12):765-72.
STUDY BACKGROUND AND OBJECTIVES: The Philippines is one of the 22 countries with high TB burden. DOTS was adopted not only by purely public providers (PP) but also by public-private mix (PPM) facilities. This study aims to identify the patient and facility factors that promote completion of TB treatment in DOTS facilities in an urban setting. The study also explores the difference between the PP and PPM DOTS facilities in terms of case management and treatment outcomes. [Methods] A case control study was done by interviewing 394 patients sampled from TB cohort report between 2003 and 2005 of 14 DOTS facilities in Metro Manila. Statistical analyses used include chi-square test and logistic regression analysis.
Being female and aged 30-44 (OR = 7.04; 95% CI 1.12-44.35), unemployed (OR = 2.73; 95% CI 1.18-6.33), being above per capita poverty threshold (OR = 2.03; 95% CI 1.03-3.99), having experienced at least one of the signs and symptoms of TB (OR = 4.64; 95% CI 1.29-16.67), taking the medication at health facility (OR = 3.87; 95% CI 1.48-10.16) and patient's understanding of DOT (OR = 2.67; 95% CI 1.37-5.23) predict TB treatment completion. Public-private mix type of DOTS facility was also significantly associated with completing treatment (chi 2 (1) = 54.76, p = 0.000).
Patient factors like middle-aged female compared to female aged more than 60, being above per capita poverty threshold, unemployment and having experienced at least one signs and symptoms of TB and facility factors like providing treatment at the facility and explaining the DOT to patient increase the likelihood of completing treatment. Thus, encouraging patients to take their medication at the facility and helping the patients understand the importance of DOT can increase TB treatment completion. The seemingly better DOTS implementation and treatment outcomes by the PPM must be evaluated further through cost effectiveness and efficiency studies.
研究背景与目的:菲律宾是22个结核病负担较重的国家之一。直接观察短程治疗(DOTS)不仅被纯公立医疗机构(PP)采用,也被公私混合(PPM)机构采用。本研究旨在确定促进城市地区DOTS机构结核病治疗完成的患者和机构因素。该研究还探讨了PP和PPM DOTS机构在病例管理和治疗结果方面的差异。[方法] 通过对2003年至2005年从马尼拉大都会14个DOTS机构的结核病队列报告中抽取的394名患者进行访谈,开展了一项病例对照研究。所使用的统计分析方法包括卡方检验和逻辑回归分析。
女性且年龄在30 - 44岁(比值比[OR]=7.04;95%置信区间[CI] 1.12 - 44.35)、失业(OR = 2.73;95% CI 1.18 - 6.33)、高于人均贫困线(OR = 2.03;95% CI 1.03 - 3.99)、曾经历至少一种结核病症状(OR = 4.64;95% CI 1.29 - 16.67)、在医疗机构服药(OR = 3.87;95% CI 1.48 - 10.16)以及患者对直接观察治疗的理解(OR = 2.67;95% CI 1.37 - 5.23)可预测结核病治疗的完成情况。公私混合类型的DOTS机构也与治疗完成显著相关(卡方值χ2(1)=54.76,p = 0.000)。
与60岁以上女性相比,中年女性、高于人均贫困线、失业以及曾经历至少一种结核病症状等患者因素,以及在机构提供治疗并向患者解释直接观察治疗等机构因素,会增加治疗完成的可能性。因此,鼓励患者在机构服药并帮助患者理解直接观察治疗的重要性可提高结核病治疗的完成率。公私混合机构在DOTS实施和治疗结果方面看似更好的表现,必须通过成本效益和效率研究进一步评估。