A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions.
作者信息
Levin Sergiy, Nowick James S
机构信息
Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA.
出版信息
Org Lett. 2009 Feb 19;11(4):1003-6. doi: 10.1021/ol802993v.
Abstract
This paper introduces a chemical model of a beta-sheet that dimerizes through parallel beta-sheet interactions in CDCl(3) solution. The model consists of two C-terminally linked dipeptides connected to a molecular template. (1)H NMR studies establish the beta-sheet folding and dimerization of the model system. This system corroborates that linking two peptide strands and blocking one edge of the assembly creates soluble, easy-to-study systems that participate in the types of interactions that occur widely in peptide and protein aggregates.
摘要
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