Wang Min-Jie, Duan Song, Xiang Li-Fen, Yang Yue-Cheng, Tu Yuan-Quan, Wang Ji-Bao, Yao Jun, Qi Jun, Jiang Yan
Cancer Hospital & Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100027, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Sep;29(9):905-8.
To study the HIV-1 drug resistance (DR) situation among newly infected persons in Dehong.
1048 HIV-1 positive blood samples from July to December in 2006 from Dehong prefecture of Yunnan, were collected. HIV drug resistance were tested using TruGene in newly infected people that were distinguished with BED-CEIA, while the subtype were determined with phylogenetic analysis using a set of reference sequences available on the Los Alamos Database.
Of sixty-four successfully analyzed samples, drug resistance mutations were detected in 4 samples with the resistance rate as 6.25%. Minor mutation in PR region such as M361/V, L63P and H69K appeared frequently and the rates were 81.25%, 70.31% and 65.63% respectively. The predominantly prevalent strains were seen as C/CRF07 _ BC/08 _ BC(65.63%, 42/64) in this study.
The prevalence of genotypic drug resistances in HIV-1 recent infections in Dehong prefecture appeared to be at moderate level. Drug-resistance surveillance program among HIV-1 infections should be continued and strengthened.
研究德宏州新感染人群中HIV-1耐药情况。
收集2006年7月至12月云南省德宏州1048份HIV-1阳性血样。对通过BED-CEIA鉴别出的新感染人群，采用TruGene检测HIV耐药情况，同时利用洛斯阿拉莫斯数据库中一组参考序列通过系统发育分析确定亚型。
在成功分析的64份样本中，4份样本检测到耐药突变，耐药率为6.25%。PR区的微小突变如M361/V、L63P和H69K出现频率较高，发生率分别为81.25%、70.31%和65.63%。本研究中主要流行毒株为C/CRF07_BC/08_BC（65.63%，42/64）。
德宏州HIV-1近期感染中基因型耐药的流行率处于中等水平。应继续并加强HIV-1感染的耐药监测项目。
Zotero 插件