Int J Cardiol. 2010 Aug 20;143(2):200-1. doi: 10.1016/j.ijcard.2008.11.168. Epub 2009 Jan 26.
Impaired functioning of the gastrointestinal system may also contribute to malnutrition and cardiac cachexia (CC) in patients with chronic heart failure (CHF). Targets for future interventions include the deranged hormonal systems involved in energy balance as well as malabsorption from the gut and dietary supplementation. Other targets are the inhibition of proteasome-dependent protein degradation and the direct inhibition of pro-inflammatory pathways. The beneficial effects of ACE inhibitors, aldesterone inhibitors and beta-blockers in preventing or delaying the collagen deposition in the small intestine wall need to be elucidated. We strongly believe that by improving our understanding of the role of the gut in CC will lead to the development of novel therapeutic strategies in the near future.
胃肠道系统功能障碍也可能导致慢性心力衰竭（CHF）患者发生营养不良和心脏恶病质（CC）。未来干预的目标包括涉及能量平衡的紊乱激素系统以及肠道吸收不良和饮食补充。其他目标是抑制蛋白酶体依赖性蛋白降解和直接抑制促炎途径。需要阐明 ACE 抑制剂、醛固酮抑制剂和β受体阻滞剂在预防或延缓小肠壁胶原沉积中的有益作用。我们坚信，通过提高我们对肠道在 CC 中的作用的理解，将在不久的将来导致新的治疗策略的发展。
